Since the first Polyurethanes book was published in , and reprinted with updates in , the world of polyurethanes has changed dramatically. This edition. Get this from a library! The polyurethanes book. [David Randall, Ph. D.; Steve Lee ;]. Introduction to polyurethanes -- The global polyurethanes market -- The life-cycle of polyurethanes -- Product stewardship -- Isocyanates -- Polyols -- Outline of.
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The polyurethanes book by, , Distributed by J. Wiley edition, in English. The way to obtain this book The Polyurethanes Book From Wiley is very easy. You may not go for some places and spend the moment to just locate guide The. Focusing on a range of components used to produce polyurethanes, this book presents an analysis of environmental issues and views on the applications for.
In addition, it was found that only a minor amount of biodegradation was seen on polycarbonate-urethanes as compared to unmodified PEUs and PDMS-PEU, thus confirming the oxidative stability of the carbonate linkage.
They found that highly hydrophilic polyurethane-polyvinyl pyrrolidone or, in contrast, highly hydrophobic polyurethane-poly methyl methacrylate IPNs elicited inert responses in vivo.
The authors concluded that the relative hydrophobicity or hydrophilicity of polymer surfaces is an important factor determining tissue compatibility. They also found that interfacial energy had no correlation with tissue responses whereas an interfacial energy near zero has been shown to be a requirement for blood compatibility.
More recently, Hunt et al further investigated the effect of changing the hydrophilicity of polyurethanes on the in vivo biological response. After intramuscular implantation, the acute and chronic inflammatory responses were evaluated by counting specific cell types and quantifying cytokines released from these cells. In conclusion, the effect of hydrophilicity, net charge, antioxidant incorporation, and chemical composition on the hemocompatibility, biocompatibility or biostability of PU surfaces is still under debate and requires clear and well-designed studies to bring quantifiable and reproducible parameters that will discriminate between polyurethanes of various chemical composition, structure and morphology.
Effect of Protein Adsorption on Polyurethanes One final thought regarding the hemocompatibility and biocompatibility of polyurethanes is to review the effects, potential benefits or drawbacks of protein adsorption on PU surfaces.
Upon implantation, one of the first events which occurs is the adsorption of proteins onto polymeric surfaces. Plasma proteins which adsorbed to the surfaces of biomaterials include albumin, hemoglobin, thrombin, fibrinogen, fibronectin, complement components, and immunoglobulins IgG. The composition of the adsorbed proteic layer is strongly dependent on the structure and composition of the polymers.
Albumin was also shown to have preferential adsorption characteristics onto segmented polyurethanes. When exposed to blood, albuminated PU surfaces were found to be less thrombogenic by masking the substrate from the blood's host defense activation mechanisms.
While intending to elucidate these interactions, a limited number of studies have looked at the intimate relationship between blood proteins and various cells involved in the inflammatory response of biomaterials in terms of chemotaxis, proliferation, and activation.
One of the most interesting and perhaps surprising results obtained by Anderson's group was the greatest activation of monocytes in terms of IL-1 secretion by various materials including Biomer which were precoated with albumin. The variability of their results was imparted to the differential protein adsorption properties of the polymers.
In a follow-up study, they reported that albumin preadsorbed on Biomer suppressed fibroblast activity in a polymer-dependent manner. In contrast, Hasper et al investigated the cellular reactions to silicone and polyurethane by measuring IL-8 and MIP-1a secreted by monocytes as well as P-selectin and platelet-derived growth factor PDGF-AB released by platelets following in vitro incubation.
Their results revealed that a Pellethane used in the production of the Berlin Heart pumps and cannulas activated the complement cascade and platelets but showed lower monocyte activation compared to silicone. By pretreating the PU and silicone surfaces with albumin, they demonstrated reduced monocyte activation IL-8 for both types of surfaces and concluded that albumin treatment could be useful in preventing inflammatory and thrombotic complications during the initial circulating support.
There is compelling evidence to suggest that among plasma proteins, albumin may be beneficial to blood contacting surfaces, such as polyurethanes, by reducing platelet and bacterial adhesion. On the other hand, albuminated surfaces may have a propensity to activate monocytes and inhibit fibroblastic proliferation.
These findings attest to the complex interactions between proteins and blood or tissue environments occurring after implantation. With the next century, the real challenge for the biomaterial scientist will be to develop polymers and structures with optimal mechanical and physical properties, biocompatibility, hemocompatibility, and biostability which can be used when constructing devices destined to replace vital organs and other tissues, thus improving and prolonging human beings' lives.
References 1. Selecting valid in vitro biocompatibility tests that predict the in vivo healing response of synthetic vascular prostheses.
Segmented polyurethanes: A polyester polymer. An initial evaluation for biomedical applications.
The Polyurethanes Book
J Biomed Mater Res. The development and implantation of a polyurethane hemispherical artificial heart. Development of block copolymer-urethane intra-aortic balloons and other medical Devices. In vivo thrombogenicity of implantable cardiac pacing leads.
Biomater Med Devices Artif Organs.
The development of nonstended trileaflet valve prosthesis. Artif Organs Japan. Polyurethane elastomers in surgery. Int J Polymeric Mater. The effects of chemical structure and surface properties of synthetic polymers on the coagulation of blood. The relationship between polymer morphology and protein adsorption.
Effect of polyurethane morphology on blood coagulation. J Bioeng. J Colloid Interface Sci.
Polyurethanes as biomaterials. Assessment of blood compatibility. Polymer Science Technology. Physiochemical characterization and in vivo blood tolerability of cast and extruded Biomer. Microphase separated structure, surface composition and blood compatibility of segmented poly urethaneureas with various soft segment components.
Effect of hydrophilic and hydrophobic microdomains on mode of interactions between block polymer and blood platelets. Hydrophilic-hydrophobic microdomain surfaces having an ability to suppress platelet aggregation and their in vitro antithrombogenicity.
Blood hemolysis by PTFE and polyurethane vascular prostheses in an in vitro circuit. Microporous hydrophilic polyurethane vascular grafts as substitutes in abdominal aorta of dogs. Hydrophilic polyurethane versus autologous femoral vein as substitutes in the femoral arteries of dogs: Quantification of platelet and fibrin deposits. Ex vivo interactions and surface property relationships for polyetherurethanes.
The biocompatibility of solution cast and acetone-extracted cast Biomer. J Bomed Mater Res. Extraction of polyurethane block copolymers: Effects on bulk and surface properties and biocompatibility.
The Polyurethanes Book by Steve Lee (2003, Hardcover)
Effect of surface hydrophilicity on ex vivo blood compatibility of segmented polyurethane. Bulk, surface, and blood-contacting properties of polyetherurethanes modified with polyethylene oxide. J Biomater Sci Polym Ed. Surface structure and biocompatibility of polyurethanes.
Clin Mater. Properties and biological interactions of polyurethane anionomes: Effect of sulfonate incorporation. Physical and blood contacting characteristics of propyl sulphonate grafted Biomer. Negative cilia concept for thromboresistance: Synergistic effect of PEO and sulfonated groups grafted onto polyurethane.
Anticoagulant effects of sulphonated polyurethanes. Polyurethanes bearing pendant amino acids: Fibrinogen adsorption and coagulant properties. Heparin like activity of insoluble sulphonated polystyrene resins. Part III: Binding of dicarboxylic amino acids. Improved blood compatibility of segmented polyurethanes by polymeric additives having phospholipid polar groups.
Molecular design of polymeric additives and their functions. Improved blood compatibility of segmented polyurethane by polymeric additives having phospholipid polar group.
Dispersion state of the polymeric additive and protein adsorption on the surface. Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties. Li YJ, Nakaya T. Synthesis of new haemocompatible phospholipid polyurethanes for biomedical applications.
Macromol Symp. Series shunt evaluation of polyurethane vascular graft materials in chronically AV—shunted canines. Effects of alkyl grafting on surface properties and blood compatibility of polyurethane block copolymers. Biocompatibility of sulphonated polyurethane surfaces. Ex vivo and in vivo evaluation of the blood compatibility of surface-modified polyurethane catheters.
Polyurethane surface modification by graft polymerization of acrylamide for reduced protein adsorption and platelet adhesion. Protein adsorption and platelet adhesion onto polyurethane grafted with methoxy-poly ethyleneglycol methacrylate by plasma technique.
A photochemical method for the surface modification of poly etherurethanes with phosphorylcholine compounds to improve hemocompatibility. Photochemical grafting of alpha-propylsulphate-poly ethylene oxide on polyurethane surfaces and enhanced antithrombogenic potential. J Biomed mater Res. Kim SW, Jacobs H. Design of nonthrombogenic polymer surfaces for blood-contacting medical devices. Blood Purif. Surface-grafted heparinizable materials.
In vitro biocompatibility evaluation of a heparinizable material PUPA based on polyurethane and poly amido-amine components. Preparation and surface characterization of functional group-grafted and heparin-immobilized polyurethanes by plasma glow discharge. Surface modification of polyetherurethaneureas and their thrombogenicity. J Mater Sci: Mater Med.
In vitro blood compatibility of functional group-grafted and heparin-immobilized polyurethanes prepared by plasma glow discharge. Heparin immobilization onto segmented polyurethaneurea surfaces: Effect of hydrophilic spacers. Water-soluble urokinase derivations of combined action.
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Share this product with your friends and family! Facebook Twitter Googleplus Pinterest Email. Product description Since the first Polyurethanes book was published in , and reprinted with updates in , the world of polyurethanes has changed dramatically.
Sold Out We're sorry to say this item has now sold out. There are over , more items in stock. Start browsing with our suggestions below. About this item. Author s: David Randall and Steve Lee Condition: Hardback ISBN Wiley Title: The Polyurethanes Book. We offer a no quibble returns policy as follows: Read full returns policy. Volunteer listed. Details Additional Physical Format: Online version: Polyurethanes book. Huntsman Polyurethanes] ; New York: Internet resource Document Type: Steve Lee.
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Cancel Forgot your password? English View all editions and formats.Thrombin time experiments showed no significant heparin-like properties to sulfonated PUs with lysine or aspartic acid although an increase in thrombin time was shown for those sulfonated PU with increased sulfonate content. NO YES. In conclusion, the effect of hydrophilicity, net charge, antioxidant incorporation, and chemical composition on the hemocompatibility, biocompatibility or biostability of PU surfaces is still under debate and requires clear and well-designed studies to bring quantifiable and reproducible parameters that will discriminate between polyurethanes of various chemical composition, structure and morphology.
As extracted Biomer was previously shown to have improved blood compatibility, 21 these results were attributed to a difference in chemistry Biomer having urea functionality or to the presence of an unknown agent in Biomer.
When reviewing the literature on the in vitro biocompatibility testing of polyurethanes, we found only a limited number of papers describing the biocompatibility of well-characterized polyurethanes. Marked inflammatory sequelae to implantation of biodegradable and non biodegradable polymers in porcine coronary arteries.
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